Safe time to warm ischemia and posttransplant survival of liver graft from non-heart-beating donors

Procurement of liver allografts from non-heart beating donors.

THE shortage of liver allografts continues to be a major limiting factor for the exploitation of liver transplantation. Although satisfactory function of allografts obtained from non-heart beating donors has been reported in kidneys I and livers,2.3 hepatic allografts have been procured almost exclusively from heart -beating donors. 4 •5 The purpose of this study was to determine the safety of ...

Prasad donors Liver transplantation from non - heart beating

Non-heart beating donors.

BACKGROUND Several groups have demonstrated that non-heart beating donation is a viable source of organs for transplantation. However, the theoretically worse graft function and survival of the kidneys obtained from non-heart beating donors (NHBDs) is still a matter of debate that has led to consider them as marginal donors for kidney transplantation. METHODS In this report, we compare the ou...

Ischemic Preconditioning of Rat Livers from Non-Heart-Beating Donors Decreases Parenchymal Cell Killing and Increases Graft Survival after Transplantation

A critical shortage of donors exists for liver transplantation, which non-heart-beating cadaver donors could help ease. This study evaluated ischemic preconditioning to improve graft viability after non-heart-beating liver donation in rats. Ischemic preconditioning was performed by clamping the portal vein and hepatic artery for 10 min followed by unclamping for 5 min. Subsequently, the aorta w...

Non Heart-Beating Donors in England

When transplantation started all organs were retrieved from patients immediately after cardio-respiratory arrest, i.e. from non heart-beating donors. After the recognition that death resulted from irreversible damage to the brainstem, organ retrieval rapidly switched to patients certified dead after brainstem testing. These heart-beating-donors have become the principal source of organs for tra...